September 22, 2026

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However, derepression out of ThPOK transcription inside the DP thymocytes regarding ThPOKCD4.Sil rats mirrors expression off endogenous Cd4 into the DP thymocytes out-of wt mice. Including, the latest SilThPOK prevents the newest transcription from Cd4 during the DP thymocytes from CD4ThPOK.Sil rats much like the suppression out of endogenous ThPOK inside the DP thymocytes of wt mice. FACS investigation of TCR?, CD69, CD4, and you may CD8 term from (b) overall thymocytes, gated thymocytes and you may (c) peripheral T-cell subsets out of wt mice or mutant lines, given that shown. Statistical benefits was computed each indicated mutant range prior to wt mice. FACS investigation out of TCR?, CD69, CD4, and you may CD8 phrase regarding complete thymocytes, gated thymocytes (c), and you may peripheral T-phone subsets (d) out-of wt rats otherwise mutant outlines, just like the shown.

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